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The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro

The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro
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Tamaño:
944.38 kB
Autor:
Leon Caly, Julian D. Druce, Mike G. Catton, David A. Jans, Kylie M. Wagstaff
Fecha:
09. May 2020
Descargas:
13 x

Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 hours post infection with SARS-CoV-2 able to effect ~5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.

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